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KMID : 0869620140310010602
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Journal of Korean Society of Hospital Pharmacists
2014 Volume.31 No. 1 p.602 ~ p.609
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The Effect of Granisetron Transdermal System Patch for the Prevention of Chemotherapy-induced Nausea and Vomiting in Adult Patients with Acute Leukemia
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Doo Ko-Eun
Han Jae-Eun
Eun Myoung-On
Lee Young-Hee
Park Joon-Seong
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Abstract
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Background : Granisetron transdermal system patch offers convenient non-invasive option and could enable continuous antiemetic effects during multi-day chemotherapy for acute leukemia patients. This study compare the effect and costs of granisetron transdermal system patch with ramosetron treatment for control chemotherapy-induced nausea and vomiting.
Methods :
Results : Total response was achieved by 51.2% of granisetron group and 45.6% of ramosetron group, but the difference not statistically significant(p=0.492). The first emetic episode occurredmedian Day1(1-9) granisetron group and median Day3(1-7) ramosetron group including patients with failure to emetic control.
Conclusions : ranisetron transdermal system patch offers reliable antiemetic effect and preferable dosing for patients receiving multi-day chemotherapy with acute leukemia, and close dosing control pharmacist is to achieve higher response.
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KEYWORD
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Granisetron transdermal patch, Chemotherapy-induced nausea and vomiting, Acute leukemia
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